Peripheral stimuli excite coronal beams of Golgi cells in rat cerebellar cortex

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Peripheral stimuli excite coronal beams of Golgi cells in rat cerebellar cortex.

Cerebellar granule cells constitute the largest neurone population of the brain. Their axons run as parallel fibres along the coronal axis, and the one-dimensional spread of excitation that is expected to result from this arrangement is a key assumption of theories of cerebellar function. In many studies using various techniques, however, it was not possible to evoke such a beam-like propagatio...

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Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cells.

Although Golgi cells (GoCs), the main type of inhibitory interneuron in the cerebellar granular layer (GL), are thought to play a central role in cerebellar network function, their excitable properties have remained unexplored. GoCs fire rhythmically in vivo and in slices, but it was unclear whether this activity originated from pacemaker ionic mechanisms. We explored this issue in acute cerebe...

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Background: Gestational diabetes mellitus affects 3-5% of all human pregnancy.Studies reported the neurotoxic effect of gestational diabetes on cerebellarand spinal cord in rat offspring. This study was conducted to determine the effect of gestational diabetes on astrocyte density in the cerebellum of rat offspring. Materials and Methods: In this experimental study, 30 Wistar rats dams were ran...

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Temporal characteristics of tactile stimuli influence the response profile of cerebellar Golgi cells.

An increasing number of studies have investigated the effect of stimulation parameters on neuronal response properties. Here, we describe the effect of temporal characteristics of tactile stimuli, more specifically the stimulation frequency and duration, on the response profile of simultaneously recorded cerebellar and cerebral cortical units in ketamine-xylazine anaesthetized rats. Long stimul...

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The function of cerebellar Golgi cells revisited.

The inhibitory interneurons of the cerebellar cortex have received very little attention compared to the granule and Purkinje cells, and Golgi cells are no exception. Theoretical considerations of the function of Golgi cell functions have evolved little since from the late sixties and experimental studies were sparse until the last few years. Recent modeling and in vivo experimental studies by ...

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ژورنال

عنوان ژورنال: Neuroscience

سال: 2002

ISSN: 0306-4522

DOI: 10.1016/s0306-4522(02)00196-3